This is interesting as during the past two months 2 of our girls were diagnosed with brain mets. Two of them were diagnosed at the same time and had similar symptoms. They both started vomiting periodically. Shortly after they were diagnosed with brain mets (metastases).
This is when the cancer jumps from one part of the body to another. Our type of triple negative metaplastic breast cancer has a tendancy to jump too.
If the sub-type is spindle cell it seems to favour the lungs. If it is Squamous it seems to favour the bones. After Stage 3 Grade 3 diagnosis then the brain comes into play – but it is less common. In four years I have only seen 4 cases of MBC brain mets.
What about the protein?
The following is from this source.
"We found that reducing the expression of alphaB-crystallin in breast cancer cells hindered the cells' ability to form brain metastases in mice," said Vincent Cryns, professor of medicine at University of Wisconsin School of Medicine and Public Health in the US.
"alphaB-crystallin may be a promising drug target that should be explored further," he added.
"Our findings suggest that alphaB-crystallin may contribute to the tendency of triple-negative breast cancers to metastasize to the brain and to their poor prognosis," said Cryns. Yet, he cautioned these findings need to be validated in additional studies.
What we think?
Proteins and the analysis of proteins are vital in pathology reports. However, little is actually done to explain these to patients or to discover what proteins are present. This must change.
This is a great article that will help you understand the treatment options for metaplastic breast caner.
This is another excellent article on MBC, which discusses the already know proteins that have an impact on metaplastic breast cancer. They are the p53 protein and the p13K.
How to react?
If you don’t have your pathology report – get it! Once you have it check for any protein positives. If you can’t find any – ask a doctor. Everyone should know if they have increased amounts of any of these proteins.
I hate to say it... but many doctors are over worked and don't have the time to do the research you need. You have to take charge.